Frontispiece from: The Canon of Medicine c.1025.
Click the image to read the full text article at the Lind Library.
Ibn Sina (Avicenna) may have been one of the first physicians to understand the difficulties of trying to extrapolate from animal species to humans.
SABRE Research UK is a British non-profit registered charity with the aim of protecting patients and research volunteers from unsound animal research data* and to promote better medical science.
Why should patients and the public be worried about data from animal models of research?
Scientific publications show that the methods used to design and translate animal research for human benefit lack scientific rigor and that the experimental data are unreliable.** This has led to the harming of patients and research volunteers. It also wastes valuable resources and research funding.
What is needed to improve data from animal research?
The 7Rs - REGISTER, REPORT, REPLICATE, RETRACT, RECORD, REVIEW AND REAPPRAISE
• REGISTER: Register past, present and future pre-clinical animal trials on an open global database.
• REPORT: Report in detail the research methods and rationale for each animal trial.
• REPLICATE: Reproduce the trials to confirm or deny validity.
• RETRACT: Retract (withdraw) any trials that cannot be reproduced.
• RECORD: Record (publish) all results of animal trials past, present and future on open access
• REVIEW: Review systematically existing animal trials before funding new animal research.
• REAPPRAISE: Reassess and monitor the value of animal research to human healthcare with large-scale programmes of systematic reviews of animal trials.
WHY :
• To improve the safety and effectiveness of medical research.
• To protect patients and research volunteers from unsound research.
• To determine the value of animal research to human health and its related research costs.
WHAT WE DO :
• We explain the scientific reasons why better science is needed in pre-clinical animal research.
• We encourage public understanding of animal research methods and bias in science.
• We support calls for open science and open access to all medical research publication.
• We offer a platform to systematic reviewers of animal trials to explain their work.
• We petition for improvements in scientific methods and evaluation of pre-clinical animal research
• We aim to raise funds for large-scale programmes of systematic reviews of animal research.
* The results of pre-clinical animal experiments that are irrelevant or misleading to human health.
** Every statement made on this website about animal research is supported by scientific publications which are archived in the
Extract from the book 'Testing Treatments':
'So, they do research in laboratories and with animals. Although such basic research is unquestionably needed, there is precious little evidence to support this bias towards it. Yet the consequence has been a massive outpouring of laboratory research that has not been properly evaluated to see how relevant it is to patients.' Click for website.
Extract from the book'Bad Pharma':
'In 2012 a group of researchers reported in the journal Nature how they tried to replicate fifty-three early [animal] laboratory studies of promising targets for cancer treatments: forty seven of the fifty-three could not be replicated.' Click this text for free and open access to the original research article.
CHARITY REGISTRATION No: 1112399
The 7Rs by SABRE Research UK is licensed under a Creative Commons Attribution 3.0 Unported License. Based on work at www.sabre.org.uk.
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