SABRE Research UK is an independent, British, non-profit registered charity.


The aim of the charity is to improve medical research by calling for systematic reviews and other evidence-based methods to assess and monitor the relevance of pre-clinical animal research to human healthcare.


Why should patients and the public be concerned about animal research?


Scientific publications show that animal studies (experiments) are unreliable because:


•   The methods used to design, conduct and translate the research are inadequate

•   The research lacks scientific rigor

•   The results often fail to predict what will happen in humans


This in turn has led to:


•   A waste of valuable resources and research funding

•   The harming of patients and research volunteers


The complex issues arising from pre-clinical animal research are not well understood, and when publicly reported and debated are rarely accurate.


We offer ten recommendations that will help to improve transparency and accountability of pre-clinical animal research - The 10Rs+


Respond - Replicate -  Register - Report - Record - Review - Regulate - Reappraise - Rationalise -  Reinvent - +Represent


SABRE recommends the 10Rs+, because it will help to achieve the following:


•   Improve the safety and effectiveness of medical research

•   Protect patients and research volunteers from unsound research

•   Determine and monitor the value of animal research to human health

•   Help to prevent waste of funding and resources in medical research


SABRE invites key stakeholders ( the public, patient's groups, funders, institutions, journals, scientists, government, regulators, industry and animal protection groups) to comment on the 10Rs+ recommendations.  












The 10Rs+ by SABRE Research UK is licensed under a Creative Commons Attribution 3.0 Unported License. Based on work at

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What do we do?


We explain the scientific reasons why better science is needed in pre-clinical research.


We encourage public interest in understanding the scientific issues and problems arising from using animal species for models of human disease in medical research.


We offer a platform to systematic reviewers of animal research to explain their work.


We petition for improvements in scientific methods and evaluation of animal research.


We aim to raise funds for large-scale programmes of systematic reviews of animal studies.


We support calls for open science and open access to all medical research publication.



"People often think that the debate is just scientists against people who care about cuddly animals and have an emotional response, rather than people who are interested in the most effective scientific methods."


Member of UK Parliament

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